PREPARATION AND PHYSICO-CHEMICAL ANALYSIS OF PRATAPMARTAND RASA AND ITS ASSESSMENT OF ANTIPYRETIC ACTIVITY IN ALBINO RATS
Pratapmartand Rasa is one of the herbomineral compound explained in Rasendrasarsangraha and indicated inJwara disease. To establish standards for quality control and provide scientific data to establish antipyretic activity by experimental study an attempt was made.
The whole study was taken up with a view of validation and setting up SOP (Standard Operative Procedure) in the preparation of Pratapmartand Rasa. The main underlying aim for the same being setting of standards – based on various parameters, mainly analytical in nature. The major problem in standardization of any Ayurvedic drug is unavailability of any set standards with which to compare a drug. This variation in processes, process being the same, a variation in the media used which are invariably herbs, and many other dependent, derived modifications created by, the workers, has lead to the conception of ‘process validation’. The Experimental study was carried out in manner to do a comparative analysis of antipyretic activity between standard drug (Paracetomal) and trail drug (i.e.Pratapmartand Rasa).
The work was conducted in two steps. First consist standardization of raw material, process and final product. Second step consist evaluation of anti pyretic activity of Pratapmartand Rasa in albino rats. In step 1 ShodhanaofTankana, Hnigula, vatsanabha and Jaypal was done according to classic. Preparation of pratapmartanda Rasa was done with reference of Rasendrasarasangraha Jwara Adhyay 2. In analytical study the ingredients and Pratapmartanda Rasaexamined for Ayurvedic and modern parameter like AAS etc. After that its antipyretic activity study was examined on Wister Strain albino rats taking as test group, control group, standard drug group each consisting 6 albino rats.
KEYWORDS:Pratapmartand Rasa, Jwara, AASAnmol Jadhav