Evaluation Of Antioxidant Activity Of Ocimum Sanctum Linn. In Eczema
Vicharchikais commonly found disease which not only affects physicaland mental healthbut also social well-being of an individual. In allopathic medicine vicharchika is being correlated with Eczema. Where oxidative stress is found to be a major causative factor &Tulasi(Ocimum sanctum Linn.) consists of plenty of anti-oxidants mainly Eugenol & luteolin. Tulasi by its katu, tikta, rasa andlaghu, ruksha guna acts as kledashoshaka&ushna veerya reduces pain in vicharchika. In ancient text various acharyas have highlighted the kushthaghna karma of Tulasi.
An open labeled parallel group study was done in Seth R. V. Mahavidyalaya Sion, Mumbai-22; 90 individuals divided in 3 groups namely, Group A receiving Tulasi churna 1gm thrice a day orally &Tulasi paste for local application; Group B receiving Tablet Cetrizine 10mg HS &ointment Betnovate for local application, Group C receiving combination of both. Subjective criteria was assessed on following lakshana- kandu, pidika, daha, strava, twaka rukshata, vaivarnyata, vedana, raji. Whereas objective criteria was assessed by checking enzyme level of SOD (Superoxide dismutase), MDA(Malondialdehyde), GSH(Glutathione).Subjective criteria is shown in %. Anova test was applied to objective criteria in Group A, Group B, Group C. F value is found to be highly significant at 87 degrees of freedom, (pooled dF) for GSH (Glutathione), SOD(Superoxide dismutase), and MDA(Malondialdehyde) at p<0.05, concluding definitely Tulasi churna isKushthaghna& an effective anti-oxidant drug.
Details: Written by Dr. Rajesh Iyer, Dr. Shraddha Chaudhari, Dr. Padma Saini, Dr. Pravin Patil
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