Today’s fast life and modern life-style is leading to faulty food and living habits of people, which has made them more prone to gastrointestinal disturbances, like GrahaniRoga. The word grahani described in ayurvedic text creates lot of confusion. The ayurvedic text shows the usage of word grahani both in context as an organ and mostly as disease. Anatomically site of grahani described in the ayurvedic text can be co-related with mucosal layers of small intestine. Also Grahani is said to be Disease which occurs due to Agnimandya & Digestive problems. Observational study was done on 30 patients of grahaniroga at Joy Hospital, Chembur, Mumbai. Subjective assessment was done on the basis of Patients Abhyavaranshakti(Intake capacity), JaranShakti(Digestive capacity), Agni parikshan and koshta parikshan with the help of prashnapariksha at Baseline. Objective criteria was OGD scopy, Colonoscopy to see the structural changes in grahani organ (small intestine) with respect to different type of grahaniroga. Also Stool analysis on the basis of Bhautikparikshan and Laboratory examination was done. Chi square test was applied to objective parameters which was highly significant at 5% level of significance. The pathological (structural) changes seen in grahaniroga are similar to the changes which are seen in certain diseases of small intestine. Also organ affected in grahaniroga is small intestine viz duodenum, jejunum & ileum. The structure (microscopic) of small instetine (grahani) i.e. mucosal layers of small intestine can be considered as site of grahani. Thus the structural changes in grahaniroga are directly related to the type of grahaniroga.

Keywords:- Grahanisharir, GrahaniRoga, Smallintestine, OGD scopy, Colonoscopy.